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Yes, the human digestive system works through muscular contractions which force the food and liquid along. This is why we have no problems in space (apart from getting the food to stay on the plate). You can demonstrate this by hanging upside down and eating a sandwich just fine.

Interestingly, the digestive system of many birds does depend on gravity; this was discovered during a Space Shuttle mission to see if birds could handle space.

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Q: Could your digestive system work without gravity?
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