Did Hades have any human descendants?

Answer 1

To my knowledge, Hades did not have children at all, divine, partly human, or otherwise.

Apparently, he and Persephone had pets, but never had kids.

Or if they did, it's entirely possible that Child Protective Services took them from the home, after noticing their home was guarded by a three-headed giant vicious dog, and was full of dead people.

In any case, while many of the rest of the greco-roman pantheon were running around having wild circus sex and extramarital affairs, it looks like Hades (even if he was a little bit stalker-ish to her), only had eyes for Persephone, and never cheated.

Maybe being surrounded by amnesiac dead people, and being hunted all the way to the center of the earth by your mother-in-law kill your sex drive, or maybe Hades, really, was the responsible brother of the greco-roman trinity, and more likely to honor the commitments of marriage.