No. At least until March 2014, he is still alive and kicking.
Wee Kim Wee died on 2005-05-02.
Pee Wee Herman
Pee Wee doesn't die in the book 'Fallen Angels'
Pee Wee Moore died in 2009.
Pee Wee Lambert died in 1965.
"Pee-Wee's Playhouse" ran from 1986 to 1991.
Wee Chong Jin died on 2005-06-05.
Pee-Wee Wanninger died on 1981-03-07.
Pee Wee Crayton died on 1985-06-25.
Pee Wee Reese died on August 14, 1999 at the age of 81.
Pee Wee King died on March 7, 2000 at the age of 86.
Leon 'Pee Wee' Whittaker died on 1993-07-22.