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It depends on the channel/transporter being blocked. For example, it's well established that a type of diuretic called a loop diuretic (eg, furosemide) causes hypercalciuria, a fancy term for excess calcium in the urine. Loop diuretics work by blocking a sodium-potassium-chloride transporter in the kidney, and indirectly result in decreased calcium reabsorption from the urine. Because most kidney stones are made of calcium, the excess urinary calcium caused by loop diuretics can predispose people to kidney stones.
By contrast, thiazide diuretics (eg, hydrochlorothiazide) commonly used to treat high blood pressure often cause hypocalciuria, which is decreased urinary calcium. Thiazides work by blocking a sodium-chloride transporter in the kidney, indirectly causing increased calcium reabsorption so less ends up in the urine. So thiazide is a reasonable medication to use for treating high blood pressure in patients prone to kidney stones.
Thiazide and loop diuretics aren't technically "channel blockers", but I'm assuming you're using the term loosely. Perhaps I'm wrong though.
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∙ 16y ago
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