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There is no such things having too much or too little GABA in the synaptic space. The GABA is either positively or negatively charged. GABA acts at inhibitory synapses by binding to specific transmembrane receptors in the plasma membrane of both pre- and postsynaptic neuronal processes. This binding causes the opening of ion channels to allow the flow of either negatively charged chloride ions into the cell or positively charged potassium ions out of the cell. This action can result in a negative change in the transmembrane potential, usually causing hyperpolarization.

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13y ago
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Q: Do clinically depressed person has too much GABA in the synaptic space?
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