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YES! Memory cells, play a huge role in your immune system. While the primary response may not use memory cells, it does produce them, in the form of Memory B and Memory T cells.

Memory B Cells have receptors for the antigen built into their membranes. When the antigen binds to these receptors, they activate the B cells. This causes the cell to undergo rapid divisions that produce more memory B cells and plasma cells (Effector B cells). The plasma cells go on to make antibodies to neutralize the pathogen, while the additional memory B cells can become activated and produce more plasma cells. This is called a humoral response.

Memory T Cells work differently. These cells have a different type of receptor, that requires the antigen to be presented on an MHC (major histocompatibility complex) molecule on an infected host cell. If an antigen for that receptor is encountered these cells can in turn activate Cytotoxic (killer/effector) T cells to destroy the host cell. This is call a cell mediated response.

In short, memory cells are a vital part of you immune system that allow for a faster response the second time you get infected. This is why you don't feel sick the second time you get a cold.

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