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Your body chemistry is always changing and trying to establish an equilibrium. Often antidepressants work for awhile and then will stop being effective. Sometimes a change in dose will help. Other times, after consulting your doctor of course, if you wean off the medication for a time and then restart, it will be effective again. A person may require another medication entirely once one stops working. It is very common for a person to stop having success with a particular medication after being on it for awhile.

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Q: Do you build a tolerance to lexapro that would make it ineffective?
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