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LSD is taken by letting it diffuse through thin skin under the tongue right to the blood stream, it ommits the digestive system. Swallowing/drinking LSD would destroy the LSD molecules because of highly acidic ph of stomach. LSD mostly focuses on serotonin receptors in the brain, but the scope of receptor types affected by this drug is enormous and the only way I can think of for LSD to be harmful to digestive system is through some highly complicated endocrine pathways in regular users, but it may have no effect at all.

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10y ago
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13y ago

LSD can cause reduced appetite and nausea in some people. Some users report increased flatulence after taking LSD. It does not alter the pH of the stomach.

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Q: Does LSD have any physiological effect on the digestive system?
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