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Lortab (hydrocodone / acetaminophen) can help reduce the severity of heroin withdrawal, since both hydrocodone and heroin bind to the opioid receptors. However, heroin is much more powerful and long-term use leads to the creation of more opioid receptors and cross-tolerance to other opioids, so it may take a significant amount of hydrocodone to experience any noticeable relief from heroin withdrawal.

From my own experience, it took 40mg of hydrocodone (4 x 10mg Lortabs/Vicodin/Norcos or related medications, 5.25 x 7.5mg hydrocodone-containing pills or 8 x 5mg of any of the above pills) to have any noticeable effect of reducing withdrawal if I had skipped my Suboxone for a day. However, I did not feel high whatsoever. Over time, it took a greater amount (typically 10x 10mg Norcos) to feel normal.

Your best route for heroin withdrawal treatment is Suboxone, if you can afford it. I would create a plan for being weaned up front to decide what should be done.

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Q: Does Lortab help with heroin withdrawal?
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