No it does not,
Mississippi River
The Mississippi River does not flow thought Pennsylvania but the Ohio River, which is a tributary of the Mississippi, does flow through Pennsylvania.
The Mississippi River.
The Ohio River forms the borders of West Virginia, Ohio, Kentucky, Indiana, and Illinois. The border terminates at the confluence with the Mississippi and the border with Pennsylvania.
Mississippi River
which river runs across the state of Arkansas
The Mississippi River is the western border of Tennessee.
Illinois is bordered by the Mississippi River on the west.
The Ohio River forms the southern boundaries of Ohio and Indiana. It begins at the Ohio-Pennsylvania border. It flows southwesterly between Ohio and Kentucky, Indiana and Kentucky, and continues to the Mississippi River.
Yes its eastern border is the Mississippi River.
The Mississippi River forms the Western border of the States of Illinois, Tennessee, and Mississippi. The Mississippi River forms the Eastern border of the States of Iowa, Missouri, Arkansas, and Louisiana.
Indiana does not border Mississippi.