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According to my pharmacist, yes. I have a reaction to Benadryl that makes me jumpy and my body itch and my legs twitchy. I got the same reaction with Tylenol PM. I can't take it, which stinks because sometimes I have trouble sleeping.

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14y ago
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13y ago

Both Benadryl and Tylenol are brand names (both owned by McNeil-PPC) used for a variety of products with different formulations, which means the answer can't be a simple yes or no.

Some of the Benadryl-branded products contain the active ingredient acetaminophen (also called paracetemol outside the US and "apap" by doctors and pharmacists) which is commonly found in the Tylenol-branded products. However, not all of them do; you'd need to look at the label to tell for sure.

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Q: Does Tylonol PM have Benadryl in it?
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Advil is fastest. Tylonol and Aleve have extra coatings.


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What are you asking? It's basically acetaminophen and benadryl


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Is there any aspirin in Excedrin PM?

No, there is no aspirin in the current formulation of Excedrin PM. Excedrin PM contains acetaminophen [Tylenol] (500mg per tablet) and diphenhydramine [Benadryl] (38mg).


Can you take Benadryl with Tylenol PM?

Yes. Although you should be careful of the amount of Diphenhydramine you are taking. Both products contain this drug. It is one of the two drugs in Tylenol PM and the only drug in Benadryl. Generally you do not want to take more 100mg of Diphenhydramine.


Can you take Tylenol pm and Benadryl together?

Benedryl (diphenhydramine) is an ingredient of Tylenol PM so you should not combine the two. Generally, just about anything that claims to be a night time formula or sleep aid will have something similar to Benedryl in it. Just about anything that says it is a daytime formula or is a decongestant will have something similar to Sudafed in it.


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You weigh 145 pounds and get high when you take 2 Tylenol pm pills is that strange?

You're not getting high, as the ingredients in Tylenol pm are acetaminophen and diphenhydramine (an antihistamine better known as benadryl). Sorry to tell you that diphenhydramine doesn't cause any effects on the central nervous system, and really can only make you drowsy. If anybody is looking for a sleep aid, it's better to just buy generic benadryl than spend the money on Tylenol pm.