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It's not that the medicine stopped working. After 10 years, your body has changed enough that the old dose isn't strong enough. SSRI medicines work by blocking the body's chemical process of breaking down serotonin - in depression, this process takes too much serotonin out of the brain, so the medication helps to restore proper levels.

Many doctors will switch between between two, or even three SSRI medications in situations like this. Once you switch out and have a "wash out" period, you can switch back to the Zoloft again and it will once more work out fine.

UGH! GASP! PUKE! How could you stand that stuff?

It put ME in the hospital.

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15y ago

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