Yes it works if you have a PS3 or XBOX360 guitar.
Guitar Hero controllers work with all Guitar Hero games, which is great! WOO!
The Guitar Hero guitar will work with Rock Band but the Rock Band guitar won't work with Guitar Hero. -Nate
Yes, all Guitar Hero guitars are compatible with every guitar hero.
Guitar Hero 2 guitars are the same as the Guitar Hero 1 guitars, so they work with guitar hero 1 and 2. If they are for the same system as Guitar Hero 3, then they will work. But that would only be with the PS2 and Xbox.
No but in Guitar Hero 5 it will work
Yes they will work
yes
yes it does
Yes
yes
indeed it does.
No, for example a Guitar Hero 2 guitar will work for Guitar Hero 3. However for the guitar to work it must be for the same system. A xbox 360 guitar will only work on a 360.