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Alcohol will not make STD treatment ineffective. However, some antibiotics should not be mixed with alcohol because you could experience side effects. The most notable of these is metronidazole (Flagyl), which is used to treat trichomoniasis. Drinking alcohol while on metronidazole, or the day before or day after, could cause severe nausea and vomiting.

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Q: Does alcohol affect STD treatment
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