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Xeloda is known to induce serious and sometimes fatal side-effects in patients with low levels of an enzyme called dihydropyrimidine dehydrogenase (DPD). DPD is the enzyme that catalyzes the breakdown of Xeloda within the body.
When you have low levels of DPD, Xeloda and its metabolite 5-Fluorouracil can accumulate to toxic levels and cause serious complications.
Patients can be tested for DPD deficiency by simple laboratory tests prior to treatment.
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∙ 12y ago
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