It should take you about four and half hours.
The driving distance from Birmingham AL to DeFuniak Springs FL is 217 road miles (using I-65 South) - about 4 hours driving time.
The driving distance between Knoxville, TN and Destin, FL is approximately 500 miles. The driving time would be approximately 8 hours 45 minutes if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work and rush hour traffic in urban areas.)
The driving distance from Houston to Jacksonville FL is 871 miles per Map Quest. The driving time to Jacksonville per Map Quest is 12 hours and 52 minutes.
6 hour
Driving time is approximately 3.5 hours.
5 1/2 hours
It is about 2 hours.
The driving distance from Jacksonville FL to Venice LA is 624 road miles - about 10 hours driving time.
New Orleans Louisiana to Jacksonville Florida is 546 miles and 8 hours 13 minutes driving time.
MapQuest estimates the driving time as 3 hours and 29 minutes. Jacksonville is approximately 201.2 miles from Tampa and Google estimates the driving time as 3 hours and 35 minutes.
The driving distance from Sanford, Florida to Powder Springs, Georgia is 459 miles and about 7 hours of driving.
3.8 Hrs