0
there are no known contraindications causing significant health risk in the combination of these two drugs. however, both are powerful chemicals, and both cause dramatically different effects, so taking them both can end up being a very confusing experience to the user. in addition, cocaine is a very nasty drug to mess around with, as is roxicodone (or any opiate), so please be careful.
Wiki User
∙ 15y ago
Wiki User
∙ 9y agoAssuming you mean anabolic steroids, that combination is likely to age you quick if not kill you with a heart attack.
Add your answer:
Earn +20 pts
How do opioid analgesics interact with alcohol?
Opioid analgesics increase the effects of alcohol. Anyone taking these drugs should not drink alcoholic beverages
What is the effect of opioid analgesics and alcohol?
Opioid analgesics increase the effects of alcohol. Anyone taking these drugs should not drink alcoholic beverages.
Is tramadol an said?
Tramadol is a mu-opioid receptor agonist. This means that it is an NSAID (non-steroidal anti-inflammatory drug). It does not contain any steroids, and so is an NSAID.
Does methadone block morphine?
Yes, Methadone will block other opioid drugs.
Acetaminophen cod 3?
Tylenol 3 is an opioid pain reliever. lt contains Codeine, 30 mg and acetaminophen (Tylenol), 325 mg.
Is naltrexone a narcotic?
Naltrexone is a narcotic antagonist, which means that it blocks the effects of any narcotic in your body. It has a similar chemical structure to some narcotics, but does not have effects on your body like a narcotic does.
Can you mix Adderall and heiron?
Mixing Amphetamines with Opiates is not uncommon. The act of which is commonly referred to as "speed balling". While the most abundant use of the term refers to mixing Cocaine and Heroin, it can apply to combinations of any type of Stimulant with any type Opiate/Opioid.
What has the author Sarah A L Marshall written?
Sarah A. L. Marshall has written: 'Probing acute opioid effects in bipolar disorder'
Does vivitrol block the effects of Adderall?
No, adderall (a mixture of pure d-amphetamine as well as a racemic amphetamine salts) works on the catechlomines (dopamine, norepinephrine) and seratonin system. Naltrexone is a mu-opioid antagonist... Amphetamine does not interact with mu-opioid.
Is neurontin an opioid?
Neurontin is not an opioid
What receptors does heroin effect?
Heroin (diacetyl-morphine) by itself has very little effect on receptors in the brain. It's main physiological effects are attributed to the conversion of heroin by the body to its metabolites morphine and/or 6-monoacetylmorphine (depending upon the route of administration of heroin). But for all intents and purposes, this is a just a pharmacological technicality, as most drugs (such as codeine) are not very active in their own right and depend upon metabolism by the liver or other organs to produce the specific effects of the drug.Heroin is an opioidergic drug and thus affects endogenous opioid receptors, acting as an agonist (meaning it plugs into and activates these receptors). It has the highest affinity for the μ-opioid (or "mu-opioid") sub receptor. This specific opioid-receptor is mainly responsible for providing all the classical narcotic effects of most opiate/opioid painkillers, including: pain relief, relaxation of smooth muscle (in the gut), euphoria, and central nervous system depression (which causes reduction in anxiety and hypertension).Like most other opiates, heroin also binds to two other opioid receptors as an agonist. First, it has moderate affinity for the δ- (or "delta-") opioid receptor. The physiological effects of δ opioid receptor agonists is not as fully understood as the other types; but it is thought to play a role in dependence and tolerance; while also providing similar effects to μ-opioid receptors agonists, primarily pain relief and central nervous system depression.Finally, heroin has some-but very low-affinity for the κ-opioid (or "kappa-opioid") receptor. The effects of κ-opioidergic drugs are extremely different than μ- & δ- opioid agonists. Effects include hallucinations, dissociation, delirium, and anesthesia. Most of the effects associated with the μ-opioid receptor do not occur with kappa agonists, including: euphoria, CNS depression, and relaxation of the smooth-muscle in the gut. Opposite to heroin, a substance that strongly binds to κ-opioid receptors, with very little affinity for μ- & δ- receptors, is salvinorin a, the active chemical in Salvia. In the 1970s, κ-opioid agonist drugs were investigated as atypical anesthetics, but were quickly abandoned due to their severely adverse, unpleasant, and hallucinogenic effects. However, heroin's affinity for this opioid receptor is minimal, even at high doses, compared to other opiates such as meperidine, which have far less abuse potential because of kappa-opioid agonist activity at higher doses.Additionally:All drugs that act as μ-opioid agonists, including endogenous endorphins, similarly indirectly impact dopamine and serotonin and induce antidepressant effects. Furthermore, heroin like nearly every other opiate, induces a histamine reaction (it is not known if this is due to an indirect or direct effect at the H1, or histamine, receptors). This can create some-allergic reactions like itchiness. Although other typical allergic-effects like watering-eyes are usually counteracted by μ-opioid agonist effects, which induce dryness in mucus membranes (such as in the mouth and eyes).Note:Unlike other opiates & opioids, heroin has not yet been shown to have any known affinity for other non-opioidergic systems in the brain, such as acting as an antagonist (i.e., a "blocking" agent) at NMDA receptors as seen with methadone (NMDA antagonists reduce glutamate levels and decrease anxiety and in higher doses can cause anesthesia, Ketamine is a potent NMDA antagonist). Heroin also has not been demonstrated to act at nociceptin receptors, like the synthetic-opiate buprenorphine. Nociceptin is a opioid-class receptor, but has opposite physiological effects, acting as an anti-analgesic; however, its overall impact upon opiate pharmacology is not fully understood.
Is tramadol hcl in the same drug class as morphine?
Technically, no. Morphine is an opioid, while tramadol is an "opioid like substance". For all intents and purposes - yes. Both act on the same receptor, the opioid receptor (mu), both act as painkillers by identical means on the opioid receptor and both are prescribed as painkillers. The difference being that morphine acts only on the opioid mu receptor (with minor affinity to the other opioid receptors) while tramadol acts on the opioid mu receptor AND as a serotonin and norepinephrine reuptake inhibitor producing its unique side effect profile among opioid like painkillers. Finally, in practice while morphine is a much stronger painkiller (due to its affinity rather than its mechanism) it has the standard opioid side effects of drowsiness, constipation, etc. Tramadol, on the other hand, reduces pain by both the opioid component and the serotonin-increasing component. This gives it approximately twice the potency it "should" have if looking at only the opioid component - the drowsiness, constipation and addiction aspects. Further, the serotonin can promote wakefulness (though not for everyone) countering some of the negative opioid side effects. This sometimes makes it a preferable to the codeine/hydrocodone type drugs, although this usually is the patients choice. Source - long term pain management patient and medical doctor, F2.
