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Definition of matrix tablet?
its the type of tablet which is designed such that it releases it contents regarding first order kineticks or zero order kinetics due to special arrangement and combination of hydrophobic and hydrophilic polymers as an excipient to form a matrix. example of such a matrix tablets are, controlled release tablet, sustained released tablet. these all come under the category of modified release tablet. by wrupesh(9558919292)
What is the difference between sustained release and controlled release drug delivery system?
Time Release Technology also known as Sustained-release (SR), extended-release(ER, XR, or XL), time-release or timed-release, controlled-release (CR), or continuous-release (CR or Contin) pills are tablets or capsules formulated to dissolve slowly and release a drug over time. The advantages of sustained-release tablets or capsules are that they can often be taken less frequently than instant-release formulations of the same drug, and that they keep steadier levels of the drug in the bloodstream. The first Sustained release tablets were made by Howard Press, in Hoboken, NJ in the early 50's and the first tablets relased under his process patent were called "Nitroglyn" and made under license by Key Corp., in Florida. Today most are formulated so that the active ingredient is embedded in a matrix of insoluble substance (various: some acrylics, even chitin, these are often patented) so that the dissolving drug has to find its way out through the holes in the matrix. In some SR formulations the matrix physically swells up to form a gel, so that the drug has first to dissolve in matrix, then exit through the outer surface.There are certain considerations for the formation of sustained release formulation:If the active compound has a long half-life (over 6 hours), it is sustained on its own.If the pharmacological activity of the active compound is not related to its blood levels, time releasing then has no purpose.If the absorption of the active compound involves an active transport, the development of a time-release product may be problematic.Finally, if the active compound has a short half-life, it would require a large amount to maintain a prolonged effective dose. In this case, a broad therapeutic window is necessary to avoid toxicity; otherwise, the risk is unwarranted and another mode of administration would be recommended.The difference between controlled release and sustained release is that controlled release is a perfectly zero order release; that is, the drug releases over time irrespective of concentration. Sustained release implies slow release of the drug over a time period. It may or may not be controlled release.
What are the release dates for Dinosaur Matrix - 1985?
Dinosaur Matrix - 1985 was released on: USA: 1985
What are the release dates for The Approval Matrix - 2011?
The Approval Matrix - 2011 was released on: USA: February 2011
What are the release dates for The Divine Matrix - 2008?
The Divine Matrix - 2008 was released on: USA: December 2008
What are the release dates for The Happiness Matrix - 2011?
The Happiness Matrix - 2011 was released on: USA: August 2011
What are the release dates for Making 'The Matrix' - 1999 TV?
Making 'The Matrix' - 1999 TV was released on: USA: 21 September 1999 (featured on The Matrix DVD)
What are the release dates for Matrix First Dream - 1979?
Matrix First Dream - 1979 was released on: USA: 1979
What are bones cells that liquefy bone matrix and release calcium to the blood called?
Bone cells that liquefy the bone matrix and release calcium into the blood are called Osteoclasts. Immature or matrix depositing bone cells are called osteoblasts.
What are the release dates for Everything Is a Remix The Matrix - 2011?
Everything Is a Remix The Matrix - 2011 was released on: USA: 3 October 2011
What are the release dates for The Matrix Online - 2005 VG?
The Matrix Online - 2005 VG was released on: USA: 22 March 2005
Is oxymorphone reformulated?
Yes. The extended release version of Opana has been reformulated to make them tamper resistant,crush resistant (to prevent users from snorting them)and has a gel matrix that will prevent users from mixing with water in preparation for injection. The instant release Opana 5 and 10 mg aren't reformulated or tamper resistant.
