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B Cell B cells begin as stem cells in your long bone marrow.
Next they develop into pro B cells. In this stage of development the variable heavy chains of their antibodies are going under recombination (V,D,J). This is a change in their DNA which is irreversible.
The pro B cells develop into pre B cells. Here the variable heavy chains have finished recombination and the mu of the constant heavy chain is expressed on the cells surface. Each allele for the heavy chain had to undergo allelic expression. You receive each allele from both your parents, however, only one may be expressed. The next step within the pro B cell is to undergo division. This is important to divide at this step before the variable light chains recombine so that you have a large immune repertoire. If your B cells divided after the light chain recombination, all your B cells would express the same antibody. Lastly in this stage, the light chains begin to recombine to add to further diversity.
After all that is finished you have your immature B cell. In this stage the light chain alleles (V,J) have rearranged. Allelic exclusion has finished for the variable chain. The antibody expressed on the cell surface is complete as IgM.
Lastly, you have your mature naive B cell. It underwent RNA splicing of the heavy constant chain and the cell now expresses IgM and IgD on its surface. The B cell is will remain a naive B cell until it becomes activated in your secondary lymphoid system. If during development the B cell's antibodies react with self antigen it will either undergo apoptosis or anergy. Either way the body ensures that your B cells do not react with self before it goes out to your secondary lymphoid system.
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What is worse b cell lymphoma or t cell lymphoma?
t cell lymphoma
Which two mature blood cell types descend from myeloblasts?
B lymphocyte (B Cell)
What disease has a b cell and t cell deficiency?
Individuals with both B-cell and T-cell deficiencies are said to have severe combined immune deficiency (SCID).
What binds with and releases chemicals that activate B cell and T cell and and macrophages?
Helper T cell
A white blood cell necessary for B cells to develop normal levels of antibodies?
Well firstly an antigen presenting cell like dendritic cell or macrophage is needed. Secondly you also need a T cell that is complementary to the B cell. B cell will only become plasma cell when it receives the full signal 1. Stimuli: CD4 from T cell interacting with BcR/antigen complex on B cell 2. Co-stimuli: CD40L (CD154) on T cell interacting with CD40 on B cell This interaction allows T cell to secrete IL4, this binds to IL4R on B cell thus receive signal for proliferating and differentiating.
What determines if a lymphocyte becomes a B cell or a T cell?
Where it is produced
T-cell lymphocytes that inhibit the activity of B cell lymphocytes?
suppressor T-cells
How helper T cell stimulate an increase in the number of B cell?
Chemical messages called cytokines that are released by the t cell. These cytokines activate transcription factors that induce B cell proliferation.
Can malnutrition cause T cell formation?
no but it causes herps
What T-cell causes the B-cell lymphocyte to multiply in response to an infection?
Activated helper T cell will multiply and become either TH1 or TH2. TH2 is the one that activates the B cell population
What does the t mean in t cells?
Thymus Lymphocytes could be roughly divided into two categories. B cell and T cell. Though they both originate from the bone marrow, T cell migrate to the" thymus," where it reach maturity while B cell got mature in the bone. That is, T stands for thymus. However, B doesn't mean "bone" actually, for B cell was first discovered in the "bursa of Fabricius" in a bird.
What is meant by T cell priming?
The first contact of a T or B cell with its specific antigen is called priming. It causes differentiation into effector T or B cells.
