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== == Natchez Trace --- I think is the answer. However it is east of the Mississippi River. If that is the river you refer to. The Natchez Trace was actually a trail used by traders who took goods down the Mississippi River to sell at New Orleans. They would take the trail back up north. It started at Vicksburg and crossed diagonally the state. See link for Natchez Trace Parkway.

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Q: From Tupelo Mississippi what Indian Trace was directly west to the Mississippi River?
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