Take the Sawgrass Expressway: I-75.
Takes about 1.75 hours.
140 miles
2 hours and 30 mins. Of course depends on where in Ft. Lauderdale and where in Ft. Myers and the time of day.
Southwest does not fly to Miami. The closest airport that Southwest serves is Ft Lauderdale.
It takes me 16 hours to drive from Ft. Myers to Cincinatti. Ft. Myers and Ft. Lauderdale are a pretty straight shot across the state so figure the same distance from Lauderdale. I think from Cinci to Cleveland is 4 hours so about 20 hrs drive.
150 miles taking I-595 WEST to I-75 NORTH towards NAPLES, then I-75 NORTH to Ft. Myers.
104 miles
It is 140.31 miles according to MapQuest.
MapQuest gives an estimated driving time of 2 hours and 18 minutes.
130 miles taking this route:Take I-75 SOUTH (towards NAPLES), from Ft. Myers, past Naples, and across ALLIGATOR ALLEY (toll) (thru the Everglades), to I-595 EAST to FT. LAUDERDALE off EXIT 19.Take I-595 EAST to Ft. Lauderdale
Fort Myers, FL
Ft myers, Panama city, tampa bay, orlando, ft lauderdale, west palm beach,jacksonville.
MapQuest gives the estimated driving time as 2 hours and 18 minutes.