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What else can I help you with?
What is the toxicity of ganciclovir?
The toxicity profile of this drug when administered systemically includes granulocytopenia, anemia and thrombocytopenia. The drug is in pregnancy category C
What seems to be the dosage at which a drug becomes posionous to the body?
It's called Toxicity. (This is the actual definition)
How do you calculate total systemic clearance and renal clearance?
Total systemic clearance (Cl_total) can be calculated by dividing the dose of a drug administered by the area under the plasma concentration-time curve (AUC) for that drug: Cl_total = Dose / AUC. Renal clearance (Cl_renal) is determined by measuring the rate of drug excretion in urine and the plasma concentration of the drug: Cl_renal = (Urine concentration × Urine flow rate) / Plasma concentration. Both clearances provide insight into how effectively a drug is eliminated from the body, with total systemic clearance reflecting all elimination pathways and renal clearance focusing specifically on kidney function.
How clearance of drug is constant in first order kinetics?
In first-order kinetics, drug clearance is constant because the rate of elimination is directly proportional to the concentration of the drug in the body. This means that a fixed percentage of the drug is eliminated per unit of time, resulting in a constant clearance rate.
Why is drug therapy monitoring used?
measure blood drug levels so that the most effective dosage can be determined, with toxicity prevented.
What are the eligibility requirements for the TSA Security Clearance Program?
To be eligible for the TSA Security Clearance Program, individuals must be U.S. citizens or nationals, pass a background check, and meet certain criteria related to criminal history, employment history, and drug use.
What lab test for the elderly would measure amount of free unbound drug molecules?
The lab test that measures the amount of free unbound drug molecules in the blood is called "free drug concentration" or "free drug level." This test is particularly important for the elderly as changes in kidney or liver function can alter the metabolism and clearance of medications, leading to potential drug toxicity or inadequate treatment. Monitoring the free drug concentration helps healthcare professionals optimize drug dosing and minimize the risk of adverse effects in older adults.
What phase in the development of pharmaceutical drugs is the drug tested on healthy human volunteers to test for toxicity and the body's handling of the drug?
phase I clinical trials
Define and explain Total Body Clearance?
Total body clearance can be defined as the volume of blood/biological fluids completely cleared of drug per unit time. It is equal to the sum of Renal clearance (CLr) and hepatic clearance (CLh).
What should be the dose of digitalis in heart failure?
The dose of digitalis or digoxin has been a problem for many years. So many patients do not tolerate the digoxin. There is toxicity of the drug. Patients feels nausea and gets vomiting. He may land up in cardiac arrhythmia, if you continue the drug. For years the patient was given a holiday on Sunday. So he was not supposed to take the drug on Sunday. Then Saturday off was also added to this. But the toxicity continued to occur. The half life of the drug is 36 to 48 hours. So when the drug is given on alternate day, it was found to work without the toxicity in almost all the patients. It may not be totally effective in this dose to control the heart failure. But that is what you get from digoxin. If you want the drug to work more, the toxicity is the result of such an attempt. If you get toxicity in alternate day dose, then your patient is in hypokalemia. You should give oral potassium supplement in such a case. Above dose is for the patients with normal kidney functions.
How did Danny Gans die?
The autopsy shows that Gans died from a drug toxicity. He had also been suffering from a preexisting heart condition. However, it was concluded that it was not drug abused related.
What is selective toxicity?
Selective toxicity refers to the ability of a drug or substance to target and kill harmful organisms or cells without causing significant damage to the host organism. This property is important in the development of antimicrobial and chemotherapeutic agents, as it helps minimize side effects and maximize effectiveness. Selective toxicity is achieved through targeting specific cellular structures or processes that are unique to the pathogen or cancer cells.
