Quite possibly not at all as your cousins' grandmother need be no blood relation to you at all on one side of their family. At the other extreme it could be you or your brother, or you could be a first cousin. Plus lots of other possibilities - for instance, your brother could have married your cousin's grandmother's daughter, making the person your nephew.
They are cousins-in-law and are not related in any way by blood.
Your uncle's sons and daughters are your first cousins.
Your great grandmother's brother is your great great uncle. Your parent and the grandson of your great great uncle are Second Cousins. Therefore you and the grandson of your great great uncle are Second Cousins, once removed.
Your son and your niece are first cousins. Her daughter and your son are first cousins, once removed.
Second cousins once removed.
If you have no siblings but your daughter has an uncle, he is the brother of your spouse, your brother-in-law.
You and your first cousin's daughter are first cousins, once removed, to each other.
Your son and your nephew are first cousins to each other. Your son's daughter and your nephew are first cousins once removed.
Your son and your nephew are first cousins to each other. Their daughters are second cousins to each other.
They are second cousins
Yes, of course your son and your great niece are related. They are first cousins, once removed, to each other. (Your great niece's parent, your niece or nephew, and your son are first cousins to each other.)
You share a common great grandparent. That would make you second cousins.