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Probably nothing major, just a different eye colour. This is not an issue at all. t's also common in border collies. The blue eye is called a "wall eye" and it causes no problems. Despite what other people may think, the eye is not blind, but it is a little more sensitive to sunlight, and more likely to develop cataracts in the dog's older age.

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Q: How bad is it to have a dalmatian puppy with one blue eye and one brown when the rest of the litter is absolutely normal?
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