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I am not sure if you wanted to know how the whole mission works, but here goes:

If the route you have chosen takes you to Out Of Commission as the final mission, then you have to take out a host of mob heavies to get through to Pegorino hiding in the old Casino. There is no timer on this, so you can take your time getting rid of them in whichever way seems to be best. Ensure you pick up their weapons as you go along. Once Niko has connected with Pegorino, the mob boss will do a runner and take to a speedboat. Niko has to fight through another group of mob bodyguards until he manages to get to a Sanchez dirt bike, waiting on the side. Niko has to hug the coastline and chase the speedboat. It is difficult, boggy terrain, but eventually he will see a ramp which he has to go up at speed in order to jump up on the helicopter which is hovering overhead, containing Jacob and Roman.

Once he has managed to get on board and started piloting the chopper, Niko has to avoid being hit by an RPG from Pegorino's speedboat too early. The chopper will eventually get hit anyway, but then the action goes into a cut scene over Happiness Island as Pegorino's boat and Niko's helicopter land there. Niko then has to chase after Pegorino into Happiness Island. The one thing I have avoided doing is stopping to fire at anyone in the way, whether it be bodyguard or cop, as long as Niko has good health he should be able zig zag through any bullets until he gets to Pegorino in the interior. Probably best for Niko to carry an SMG so that he can run faster and also be able to take out Pegorino. If Niko is successful, the action should go into a cut scene with Pegorino's dying moments.

Useful tip: Before Niko connects with Pegorino in the casino (as there is no timer on this mission), take Niko back up the road to the garage on the hill, behind the Casino complex. There is a building next door with a ledge, with a rubbish skip on wheels which Niko can get up on to get at the armour hidden on the ledge above. This will top up his armour before the worst of the action. There are two first aid boxes inside the Casino itself, so that will help too.

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Q: How can I kill Pegorino in Grand Theft Auto IV?
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