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How can adrenergic drugs be structurally modified to be beta 2 selective?
Wiki User
∙ 6y ago
The amino group of the adrenergic drug can be substituted with a bulkier amino substituents to enhance beta activity. OH groups can also be added to positions 3 and 5 of the benzene ring of the drug to cause beta 2 selectivity.
Wiki User
∙ 6y ago
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How can adrenergic drugs be structurally modified to have a longer duration of action?
It can have one less OH group than catecholamines. The new structure will not be recognised by metabolic enzymes so the drug will not be degraded by COMT.
How are anerexiants different from amphetamines?
Although these drugs are structurally similar to amphetamine, they cause less sensation of stimulation, and are less suited for use in conditions characterized by lack of adrenergic stimulation.
What is a anti-adrenergic drug?
Antiadrenergic drugs decrease or block effects of sympathetic nerve stimulation, endogenous catecholamines (e.g. epinephrine), and adrenergic drugs.
What are the most common side effects of Adrenergic Drugs?
The most common side effects of adrenergic amines are nervousness, agitation, and wakefulness
How beta adrenergic drugs cause diabetes?
increase bp and heart rate
What has the author Tsuneyoshi Tanabe written?
Tsuneyoshi Tanabe has written: 'Cardiac glycosides and adrenergic activity' -- subject(s): Physiological effect, Drugs, Adrenergic mechanisms, Glucosides, Heart
How can adrenergic drugs stimulate the adrenergic nerves?
This is done through several mechanisms: - Stimulating noradrenaline to be released - Mimicking noradrenaline's action on the receptors -Preventing noradrenaline to be broken down and reuptaken
What are alpha1-adrenergic blockers?
Alpha1-adrenergic blockers are drugs that work by blocking the alpha1-receptors of vascular smooth muscle, thus preventing the uptake of catecholamines by the smooth muscle cells.
What drugs decrease ADH levels?
Drugs that decrease ADH levels include alcohol, beta-adrenergic agents, morphine antagonists, and phenytoin (Dilantin).
Why are adrenergic agonists used as ophthalmic drugs?
They work on the eye the same way as the nasal decongestants. A-adrenergic receptors are stimulated on small arterioles in the eye and conjuctival congestion is temporarily relieved through arteriolar vasoconstriction.
Why Pesticides and cancer drugs are both created by?
Selective breeding
What does substitution of the amino group of adrenergic drugs result in?
Since the alkyl substituent is made bulkier, the beta activity of the drug will be enhanced.
