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If the base hydrolysis mechanism is important, an electron withdrawing group can be attached to the prodrug. If the acid hydrolysis mechanism is important, an electron donating group can be attacked to the prodrug.
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How can the hydrolysis rate of prodrugs be slowed down?
The hydrolysis rate of prodrugs can be slowed down with the usage of sterically hindered esters and the use of long-chain fatty acid esters.
How are carrier-linked prodrugs activated?
Carrier-linked drugs are often activated through hydrolysis.
What functional groups are the most common in prodrugs?
They are alcohols and carboxylic acids. They are usually activated by hydrolysis.
What is the theoretical rate constant value for hydrolysis of ethyl acetate?
The rate constant value for the acidic hydrolysis of ethyl acetate is in 10-3 and for alkaline hydrolysis is in 10-5.
Do people with red hair fall victim to a more accelerated rate of tooth decay?
There is no proof that red hair people have a more accelerated rate of tooth decay. Those that do not brush their teeth, have a more accelerated rate.
Accelerated depreciation method?
Accelerated depreciation is method in which double rate for depreciation is used as compare to straight line method.
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An accelerated junctional rhythm has a heart rate between 60 and 100. Meanwhile, a junctional tachycardia has a heart rate >100.
What does rapidly mean?
Rapidly means quickly, taking place at an accelerated rate.
What Rapidly mean?
Rapidly means quickly, taking place at an accelerated rate.
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universe is expanding at an accelerated rate.
What can cause an accelerated heart rate in a fifty year old woman?
could be number of things...stress, anxiety, being active, depends on the situation in which it accelerated!
Is motion of a balloon ascending at a rate of 14 meter per second is accelerated or decelerated?
since the balloon is moving up with a constant speed it is not accelerated or decelerated
