How can you breed brother and sister rabbits?

It is not recommended to breed closely related rabbits, especially litter mates. There is a very limited gene pool when you line-breed that close and can in some cases lead to mutations/deformities. The deformities may not always be visible as some GENETIC mutations will not cause physical deformities, it all depends on how the chromosomes match up. Some kits may be perfectly fine, but others can have severe and noticeable deformities, some of these deformities can be blindness, deafness, abnormally grown limbs, or they can also be stillborn.