Colcichine inhibits the formation of spindle fibres during early metaphase.Thus the cell division process stops during late prophase.micotubule has 2 ends.+ end or - end.in microtubule growth addition of tubulins(subunit of microtubule) is much faster than removal of it at - end.but if we supply cochicine to the cells,new tubulins will form complexes with colchicine and when these tubulins added to + end,further elongation is inhibited,but removal of tubulins at the other end is still continuing,so we speak about degradation of mcrotubule.the end result is division process stopped,because now,metaphase is not possible.
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