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In what time period? The Mediterranean (it also used to be called the "White Sea" by the Turks in medieval times) has been in use by people for tens of thousands of years, so it would help to narrow down the time period and/or people's you're talking about.

In general, it's sometimes been called the birth of sea commerce, because of all the ancient cultures that used it to transport trade goods between nations. It's also provided a temperate climate, even during the Little Ice Age, and water in areas where there aren't usually much to be had (specifically along the southern shores), which has affected agriculture.

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