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First off, lie detectors are not real. The closest thing to it would be a polygraph test, and that does not determind if one is lying. The test measures certain physical characteristics (such as heartrate, blood pressure, skin conductivity, respiration, to name a few) and determines if any of those change upon the testee being asked a question. This, combined with an experienced examiner, can help determine if the testee is lying; though it can not say so for certain.

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