Here are some sentences.
It is cruel to make fun of someone.
Don't be cruel to her.
"Can you use cruel in a sentence?" is a sentence, so yes, unless you mean something else?
Being cruel is not an innate condition.
In the 1960's people were very cruel to blacks,
This seems a very cruel fate for an innocent, harmless sheet of paper.
The citizens were oppressed by their cruel dictator.
Do not be cruel to animals.Why are you so cruel to me?Her actions were very cruel.
Why are you so cruel to me?That was a very cruel thing to do.
Infidelity is rampant among the selfish, cruel leaders.
Genghis Khan was notoriously cruel.
children
As Cruel as School Children was created on 2006-07-25.
Don't be cruel to a heart that's true.