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There are at least 2 ways:

1.Accidents. Often scientists will stumble upon new phenomena as they are attempting to prove or disprove something else. The new and unexplained phenomena ends up being more scientifically relevant than what they are initially trying to prove. An example of this would be Marie Curie accidentally discovering radium, or Percy LeBaron accidentally discovering that microwaves can be used to heat materials.

2.The Scientific Method (hypothesis testing). In hypothesis testing, a scientist will establish a hypothesis, then test his theory to determine if the hypothesis is true or false. He often uses a control group to compare his experiment to, to determine if the results of the experiment were substantial enough to prove the hypothesis. Hypothesis testing relies on accurate and detailed observation, measuring, and recording of data.

New information comes about when a scientist has proven or disproven a hypothesis.

An example of a famous hypothesis test would be Galileo's experiments with gravity on the leaning tower of Pisa. Galileo hypothesized that a heavier object would fall faster than a lighter object. He conducted an experiment in which he dropped two objects of different weights simultaneously to see which hit the ground first. He recorded the data, and repeated the experiment several times until he was sure of the results. The new knowledge that he gained was that any two objects would hit the ground simultaneously, regardless of weight.

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