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RBCs lose their nucleus for the sole purpose of achieving their bi-concave shape. This shape allows RBCs a greater surface area which helps with the diffusion of many gases into and out of RBCs than lets say a sphere. They not only lack a nucleus but various other organelles which prevent them from carrying on extensive metabolic activities. WBCs keep their nucleus because they have specific jobs of fighting against microbes. They need their nucleus to do their job, while RBC's don't.

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Q: How do red blood cells lose their nucleus when white blood don't Both RBCs and WBCs are created in the bone RBCs nucleus is squeezed out by the tight fit but WBCs keep theirs Y?
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