"Will the new rules affect me?" "the medicine affects my heart rate" "This new ruling affects your business"
Her winsome ways do not affect me.
my contributions affect everyone in my organization.
talking down to carl could affect his self esteem
It depends what the sentence is. Affect is a verb, effect is a noun. Eg. The blast affected her health. The effects of the blast were catastrophic.
"Natural disasters affect many people's lives."
Staying out in the sun too long may affect your ability to reason.
The misfortune that had befallen her did not affect her merriness.
An example sentence could be: "Can I inflate your car tire for you?"
How did Freemasonry affect George Washington's life?
The actions of an officer affect the respect held by the community for the local enforcement agency.
The detectives were suspicious of the recent widow's carefree, almost giddy affect.
You say 'profound effect'