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Some molecules are very simple, such as an oxygen molecule with two oxygen atoms; the structure of that molecule is obvious because there is only one possible structure for two atoms to have. Other molecules are tremendouly complicated, such as DNA, the structure of which (the famous double helix) was inferred by Watson & Crick based on an examination of X-ray crystallography of the substance. In many cases molecules are assembled from smaller pieces whose structure has already been studied and is known. A great deal is known about how different elements and different radicals combine with each other based on their valences and shapes (radicals have a variety of shapes, elements are all spherical atoms) so reasonable inferences can be made very often. There are various enzymes that can be used to cut molecules are specific locations, to help investigate their structure. Many different techniques are used.

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