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I wouldn't flush it as flushing as been known to ruin the transmission. Your van has a drain plug. When the van is cool, place an oil drain pan under it and drain the fluid out. You should drain about 5 quarts. Then loosen all the little bolts, drop the pan, clean off the old gasket, replace the filter and put the pan (with new gasket) back on. Be careful because too much pressure can cause the little bolts to snap off. Then you really have a problem. After you get it put back together , add your new transmission fluid. Yes, it will comingle with the remaining old fluid. I do the above procedure then just drain the Transmission Fluid the next time I change the oil and add more fresh. Do this a several times per year and you will be running mostly newer fluid. My 2001 has 162000 miles on it and I drive it on long trips all the time.

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Q: How do you flush a transmission fluid on a 2000 Nissan Quest?
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