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The most natural method of abortion is medical instead of surgical. Surgical abortion is very unnatural and invasive. Medical abortion is commonly done by use of a mifepristone (RU-486) pill, which blocks progesterone, the hormone that is needed to sustain abortion. This blocking of progesterone causes the softening and opening the cervix, and changes the uterine lining, resulting in detachment of the pregnancy. Mifepristone is usually used with misoprostol, a prostaglandin which causes the uterus to contract and the woman to push out the detached tissue.

Undergoing this method of abortion is similar to having a miscarriage, the natural termination of a pregnancy.

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