Well, it depends on where you're coming from. But generally speaking, you will need to take the 4-5-6 (the green line, aka the IRT or the Lexington Avenue line). The 4-5-6 is currently the only subway line that goes up and down the East Side.
You could also take the N, R, or W (of the N-R-Q-W, the yellow line) to Lexington Avenue-59th Street. Lexington Avenue is three blocks east of Fifth Avenue.
Or, you could take the E (of the A-C-E, the blue line) or the V (of the B-D-F-V, the orange line) to East 51st Street-Lexington Avenue. That is the last stop on the Uptown E or the V before they go to Queens (and the first stop on the Downtown E or V fromQueens).
See the Related Link below for a complete NYC subway map.
Second Avenue Subway was created in 2016.
Take the Uptown E train (of the A-C-E, the blue line) from 34th Street-Penn Station to 53rd Street-5th Avenue. Fifth Avenue is one block west of Madison Avenue.
Take the Uptown 6 train (of the 4-5-6, the dark green line) from 33rd Street (at Park Avenue) to 86th Street (at Lexington Avenue). Park Avenue is the next avenue east of Madison, and 3rd Avenue is the next avenue east of Lexington.
The Setai Fifth Avenue was created in 2010.
Fifth Avenue Synagogue was created in 1958.
One Fifth Avenue was created in 2008.
Chrysler Fifth Avenue was created in 1982.
Fifth Avenue Mile was created in 1981.
Fifth Avenue Hotel was created in 1859.
The duration of It Happened on Fifth Avenue is 1.93 hours.
Saint Marks Avenue - BMT Fifth Avenue Line - ended in 1940.
There is no such thing as a 1998 Chrysler Fifth Avenue