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Opioid Tolerance has been shown to be regulated by NMDA receptors. When somebody takes an opioid glutamate is released in the brain and binds to the NMDA receptors causing an increase in opioid tolerance. There have been several studies that show that taking and opioid with a NMDA antagonist (a drug that blocks NMDA receptors, effectively "turning them off") prevents the development of opioid tolerance. An accessible NMDA antagonist is DXM or Dextromethorphan which is found in many different cold medicine preparations. Be careful if taking a multiple ingredient cold medicine as many contain acetaminophin and other ingredients that can be dangerous if taken in high doses. Hope this helps, I included a link to a study if your interested.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2045628
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∙ 14y ago
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Is vicodin 7.5 a good pain reliever?
Yes it is depending on your opioid tolerance
Is it true that Tolerance to a particular drug might also increase drugs in the same class?
Yes it can especially with opioid narcotics its called cross tolerance
What is meant by the phrase Tolerance Limits?
The extreme values (upper and lower) that are permitted by the tolerance
Does a greater tolerance for alcohol lower a persons BAC?
No
Is there a way to rapidly and significantly lower one's tolerance to THC?
No the only way to reduce tolerance is to not use the drug for a period of time.
How does it nicotine tolerance to go away?
For a complete guide on how to get rid of nicotine tolerance visit ehow.co.uk/list_6860337_ways-lower-nicotine-tolerance.html
What is h9 tolerance limit for a 8mm diameter shaft?
UPPER TOLERANCE: 0.0MM LOWER TOLERANCE: -.062MM Source: Michelin Quality Requirements Manual 1993
Is it true that skinny people have a lower tolerance for freezing temperatures?
yes
Is neurontin an opioid?
Neurontin is not an opioid
What is the most most used and the strongest opioid?
I'd say: Dilaudid (Hydromorphone) 10 mg (lower is more sensible).
What is the meaning of tolerance as applied to a dimension?
Tolerance is the allowable variation for any given size in order to achieve a proper function. Tolerance equals the difference between lower and upper limit dimensions. For example; for 0.500-0.506 inch the tolerance would be 0.006 inches.
Which of these is one effect of opioid abuse?
Opioid drug users may appear slowed in their physical movements and speech, may lose weight, exhibit mood swings, and have constricted (small) pupils.
