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Permanently paralyzing any limb is usually caused by a spinal or nerve injury. There would be no way to actually selectively do this. Even surgically, things could easily go seriously wrong (beyond losing the use of a leg). It is hard to predict what nerves or spinal injuries are going to affect.

Sometimes temporary paralyzation can be done with pharmaceuticals when introduced just the right way, usually through the spine, but that would only have temporary effects. It is also a procedure that can be prone to complications.

Automobile and motorcycle crashes are the leading causes of spinal injuries. A spinal injury can cause a variety of issues, including total paralysis and loss of lung function.

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Q: How do you paralyze the human leg?
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