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Mane is the hair on the neck of a horse. Main is chief in size, extent, or importance; principal; leading. mane, freeing up his hands to draw his knives. When the meal was over, I sought him out in the main room while the other crowded around the kitchen cleaning up.> If you want both of them in a sentence together you could put, "Be sure to shake your mane when you arrive at the main hallway." or "The mane of these plains is the main predator. "

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