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Compared to other more basic molecules, glucose is rather large. In order for glucose to enter the cell in the first place, the cell must actively transport it from outside the cell wall using special transport proteins. This is compared to a cell passively transporting molecules, where the molecules are small enough (or non polar) to pass through the cell membrane without any action from the cell itself.

Once the glucose is in the cell, there is no way to get out.

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