not to day
Dopamine.
Cocaine is an agonist to the dopamine receptor. Because it is an agonist, cocaine sits on the dopamine receptor, thus inducing dopamine chemicals to flood into the brain and body. Dopamine makes a person feel euphoria......
Pure Cocaine (benzoylmethylecgonine) does not contain any other ingredients. Cocaine asts as a Dopamine Reuptake Inhibitor, Dopamine is an organic compound used to regulate hunger. Cocaine stimulates Dopamine transmitters in your brain, which,among other things, gives it appetite suppressing effects.
Dopamine is an " award " neurotransmitter, so abuse of drugs could be linked to dopamine.
Cocaine is known to block the reuptake of dopamine, serotinin, and noradrenaline which are all key neurotransmitter systems involved in regulating emotion. However, it is via the effect on dopamine in the ventral tegmental area that is thought to be primarily responsible for mediating sensations of pleasure and self reinforcement.
Dopamine
Cocaine is a dopamine reuptake inhibitor, causing a build-up of dopamine in the brain. That build-up is associated with the euphoric sensation often referred to as a "high."
Dopamine in ecstasy can lead to increased feelings of pleasure, euphoria, and social bonding. This can result in increased risk-taking behavior, heightened impulsivity, and decreased inhibitions. However, prolonged use of ecstasy can deplete dopamine levels, causing mood disturbances and cognitive impairments.
The effect of dopamine on the cells of the GPi is to suppress them by preventing them from firing.
Cocaine and crack cocaine are psychostimulants that affect neurons containing dopamine in the areas of the brain known as the limbic and frontal cortex. When cocaine is used, it generates a feeling of confidence and power. However, when large amounts are taken, people "crash" and suffer from physical and emotional exhaustion as well as depression.
blocking the dopamine or monoamine reuptake into the presynaptic axon ending
dopamine