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Your body uses up its stores of ATP (produced in the mitochondria) and the fatigue is the ensuing result. As well, once the ATP is depleted your body switches over to an alternative form of energy that produces toxins -what we call lactic acid. Its the build up of this toxin that makes your muscles sore.

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Depletion of stored glycogen causes?

fatigue....


What factors cause fatigue from prolonged exercise?

The evidence Fatigue during prolonged exercise is definitely associated with depletion of glycogen stored in the liver (causing hypoglycaemia - low blood sugar) or in the muscles


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