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Hydrocodone & tramadol are both opioid agonist analgesics. They are both micro (morphine) agonists, and (unlike buprenorphine), they are both full agonists, and not partial. Although tramadol's chemical structure is simpler than that of hydrocodone, its pharmacology is more complex. And even though their pharmacologies differ, somewhat, both share key features related to the prototype narcotic, codeine. Both tramadol and hydrocodone share a 3-methyl ether grouping (as does codeine), and all three are demethylated by the liver to corresponding, more active phenols. Although tramadol is arguably a less potent analgesic than hydrocodone, it is difficult to compare and contrast the relative ratio equivalencies between the two, because hydrocodone's absolute potency equivalency has not been established. In other words, unlike many other narcotics, experts do not agree on how potent and efficacious hydrocodone really is. Most believe hydrocodone is less potent than oxycodone, but the extent of the reduced potency here is debatable (the relative differences in potency between the analogous hydromorphone vs oxymorphone (Dilaudid vs Numorphan), is more straight forward. Tramadol has significant SNRI action, while hydrocodone does not. Interestingly, however, both hydrocodone and codeine can cause seizures, but not as readily as tramadol (or pethidine, for that matter). There is some evidence that hydrocodone, along with codeine and oxycodone, might have very mild SNRI effects, just as tramadol does, but much weaker. Tramadol itself is a very weak opioid agonist, and most of the opioid agonist effect derived from the compound is through a hepatic demethylation. However, unmetabolized tramadol has a rewarding effect (dopamine, rat, NAC shell) clearly in greater potency than is accountable by its very weak mU opioid effect. Could it be that unmetabolized (parent) tramadol behaves similarly to the drug MDMA, and that the metabolised M1 is similar to hydrocodone? Now, a portion of the human population can not effectively perform 3 ortho demethylation, and these people probably will derive lesser analgesic benefit from tramadol, codeine, and even hydrocodone and oxycodone, and in this rank ordering of significance. Tramadol is a synthetic analog of codeine. Hydrocodone is a conger of codeine, as is oxycodone. Phenomenologically, it is best to think of tramadol as a weak version of ketobemidone, for those in which the drug is efficacious. Both analgesics raise the seizure threshold, and both are nmda-antagonists. The specific "leg pleasure" both drugs produce, coupled with not wanting to move one's body whatsoever, is a striking similarity. It would appear, perhaps, that not only does tramadol have far greater abuse potential than previously thought, but that, in fact, tramadol may represent one of the most abusable of all opioids, and even greater than heroin.
What else can I help you with?
Is ultram like a Vicodin?
No. Ultram is tramadol HCL. It is a completely different drug that hydrocodone (Vicodin) with a different therapeutic action. Standard dose for standard dose, hydrocodone is somewhat more powerful than tramadol.
Is sulfur in tramadol hcl?
No, sulfur is not an ingredient in tramadol hydrochloride (HCl). Tramadol HCl is the active ingredient in the medication, which is a pain reliever used to treat moderate to severe pain. It does not contain sulfur.
What does the hlc stand for after tramadol?
Oh, that's a good question, friend! The "HCL" after tramadol stands for hydrochloride. It's a common way to indicate the specific form of the medication. Just a little detail to help us understand how the medication is made.
What is the difference between Tramadol and Tramadol HCI?
You can find HCl suffix after many medicine contents. The difference is Tramadol HCl has a better bio availability than Tramadol, that means more portion of the medicine may be absorbed through the intestine. EXPLANATION: The stomach has an acidic environment. Tramadol HCl is a weak acid, so it will less ionize in acidic environment and only unionized molecules are absorbed through the gut. So Tramadol HCl is better at being absorbed through the gut than Tramadol.
Does Tramadol HCl cause sleepiness?
Yes, it does.
Is 50mg of tramadol the same as 50mg of tramadol hcl?
Tramadol: the whole pill works within an hour. Tramadol HCL: extended release and will work all day long. You can just chew the Tramadol pill and it will get the same effect, i always chew all my eight or ten 200mg tramadol pills
Is trimadol a narcotic?
no. the medication Ultram (tramadol hcl) is non-narcotic; even though they have the same effect as hydrocodone if taken in high doses.
Does Tramadol HCL contains cocaine?
Pure tramadol HCl does not contain contain cocaine, as tramadol and cocaine are two different substances. However, it is possible that something sold on the street might contain a mixture of these two chemicals.
Is tramadol hcl comparible to Vicodin?
No , the difference being : the non-ionic - organic form of tramadol (opioïde) with a basic R-NH2 group at one end, versus the ionic (salt) form after reaction with HCl (acid) : R-NH2.HCl. (Compare NH3 + HCl -> NH4Cl , or re-written as HNH2 + HCl -> HNH2.HCl a.k.a. ammonium chloride)
Can tramadol hcl be used for gout?
I suffer from occasional gout flare ups. I find narcotic pain medicines like hydrocodone/APAP 5/500 are more effective. Tramadol is still effective, just not as effective for relieving the intense pain associated with gout in comparison. I personally feel the same drowsiness side effects from both drugs but Tramadol lacks the euphoric feelings.
Can Darvocet and tramadol hcl be taken together?
Yes, in moderation, of course.
Can you inject tramadol hcl?
Tramadol is a type of painkiller. It is prescribed more often in pill form, so unless a person is in the hospital, it cannot be injected.
