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drugs get metabolised (broken down) at different rates.

Some drugs are metabolised quickly, therefore have shorter half lives and more frequent dosing to maintain optimal levels.

some drugs take longer and need less dosing.

Other things can also affect half lives

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Q: How does the half life of a drug affect withdrawal?
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What medications are given for alcohol withdrawal?

librium because of its short half life


Does increasing the drug dosage increase the half life?

No....It will feel stronger and more potent, but the half life remains the same for each drug......I think?


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Dear Sir All the medicine have half life. half life is the time that when 50 per cent of drug goes out of the body. it is important because when the kidney or liver failure exist the drug remains in body and toxic reactions occurs. ------ See the link below for the half-life of radioisotopes.


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Plasma half life is the most important factor determining the dosage frequency. it also decides the time taken for the drug to reach steady state plasma concentration, which takes about 4-5 half lives to achieve. we can calculate how long the drug is going to stay in the body by knowing its half life as it is the time taken for the drug concentration to halve.


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The answer to this is somewhat complicated. Some of this depends on the dose and the elimination half life. The higher the dose, the longer it will take for your body to eliminate it. This is just common sense. Half-life indicates the amount of time it takes for the body to eliminate half of the remaining dose. After one half life, half of the original amount remains. After two half-lives, one-quarter of the original amount remains and so on. However, you asked about withdrawal. Withdrawal is a complex phenomenon that depends on how long you have been using this medicine and at one dose. All humans build up a tolerance to the effects of this agent. Restated, you will need more and more drug over time to achieve the same effect. The name for this is "tolerance" and it should not be confused with addiction as they are not the same. Tolerance depends on the length of time the drug has been used and the dose. Withdrawal occurs when there is a sudden reduction in the dose. While withdrawal is not dangerous, it is unpleasant. There are medicines to address this problem that you can obtain from your physician. Withdrawal can be minimized by tapering the dosage slowly as well. You should also discuss this with your physician. Do not try to do this on your own. You really need to discuss this with your treating physician.


Can you extend the half-life of opiates?

I am a doctor managing many opium depended patients. If a depended patient withdrawn from his/her opium for some 24 hours, he/she will suffer from an unpleasant syndrome called "Withdrawal syndrome". Therefor we can say that the half life of opium may be 6-12 hours.


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