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Hypokalemia potentiates the effects of digoxin. Hypokalemia reduces the drive of the Na-K-ATPase, resulting in increased cellular Na in cardiac muscles. Digoxin does the same thing by blocking the Na-K-ATPase.

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Q: How does the hypokalemia affect the effects of Digitalis?
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What is the effect on the heart function in the case of hypokalemia and hyperkalemia?

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