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Basically, it's marriage to genetics. Early 20th century geneticists thought that natural selection was too weak to take random mutation and do anything with it. The founders of population genetics and systemists in Biology by mathematical paraphernalia showed that gradual allele frequency change over time in populations of organisms was possible ( supported by experiment since ) and jumps in mutational events were not necessary.

Plus the fact that Darwin's original theory had a mechanism of heredity, blending, that could not work with natural selection.

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Q: How does the modern synthesis theory of evolution differ from Darwin's Theory of Natural Selection?
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What was Darwins process of evolution called?

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