If you take US 65 the whole way, it's about 380 miles. Going via I35 to Kansas City and making your way back southeast from there through Peculiar, Clinton, and Springfield is slightly longer (about 400 miles) but probably faster.
It is 802-805 miles which is 12 hours and 32-34 minutes.
Brooklyn, Missouri.
90 miles
12 miles
The driving distance from Branson MO to Des Moines IA is 399 miles per Map Quest. The driving time per Map Quest is 6 hours and 9 minutes.
It is 114 miles according to Google Maps.
619 miles
42 miles taking U.S. 65 SOUTH.
It is 144.28 miles according to MapQuest.
It is approximately 54 minutes to go from Branson, MO to the Springfield airport.
It is 128 miles according to Google Maps.
It is 1,059.00 miles according to MapQuest.
roughly 1200 miles